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A
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Source-
Yahoo Biotechnology Online
5/30/01
Gene
Linked to Schizophrenia
| Scientists
have found a mutant gene that may be linked to the mental disorder,
schizophrenia.
Schizophrenia alters a person's behavior
and thought processes. One percent of the world's population is
affected by this disorder.
Studies were done on 175 patients with schizophrenia.
These patients were more likely to have the variant COMT gene. Normal
COMT gene helps process dopamine, a neurotransmitter (a chemical found
in the brain). The variant or mutated gene is less active.
The results, also, showed that
schizophrenia is caused partly by a gene that affects the levels of
dopamine in the prefrontal cortex, which is responsible for judgment
and abstract thinking.
Scientists hope that a drug could be
developed to interfere with the function of the mutated COMT gene,
which may then reduce the severity of the disorder. |
Source-
Siliconvalley.com 
5/23/01
Human
Genes in Plants?
| Scientists
are genetically altering plants to produce human proteins that might
help many diseases in the future.
According to Epicyte (San Diego)
President Mich Hein, plants are the most efficient producers of
proteins on the planet since they get their energy from the sun and
all their nutrients from the soil.
The procedure is done by removing a gene
that makes a specific protein from a human cell and inserting it into
a plant or animal.
Immunex created three years ago a
modified human protein grown in animal cells for rheumatoid arthritis
treatment. The drug has been a great success for disease treatment.
However, using plants rather than animals will be a safer way of
producing human proteins, since plants do not get infected with
viruses that infect animals.
Engineered plants need to be produced in
areas where the pollen cannot spread to other crops, especially, to
those that are consumed by humans. |
Source-
Yahoo Biotechnology Online 
5/17/01
Genes
May be Involved in Cholesterol Levels
| Scientists
are exploring a link between genes and high levels of cholesterol,
which is a major source of heart disease.
Inherited high cholesterol happens when
the liver cannot clear fats from the blood. LDL (Low Density
Lipoprotein), known as the "bad" cholesterol is
significantly high compared to the "good" cholesterol, HDL
(High Density Lipoprotein) in patients with high cholesterol
levels.
Many people consume high fat diet,
however, not everyone develops heart disease. Researchers are
looking for susceptibility genes for high cholesterol levels within
the population.
Recently, scientists have reported a
genetic defect linked to a heart disease, known as autosomal recessive
hypercholesterolemia. It has been shown that in some people with this
disorder, a group of genes affect LDL levels. |
Source-
Washingtonpost.com 
5/9/01
Rough
Map of Mouse Genome is Done
| Scientists from drug
companies, as well as, government laboratories have completed a rough
map of the mouse genome.
The mouse map is important in finding
new drugs and sorting out productive genes from unproductive genes
common to both mice and humans.
Dr. Collins, director of the NIH Human
Genome Project, said that the agency is committed to accurately
finishing the mouse genome by 2005. |
Source-
Yahoo Biotechnology Online 
5/1/01
Genes
Involved in Alcoholism and Depression
| Scientists have
discovered genetic predisposition for alcoholism and depression.
The new discovery will help diagnose
depression and alcoholism that run in families.
The study was based on information
gathered from several hundred families with more than one case of
alcoholism. |
Source-
BBC News 
4/30/01
Dogs'
Sight is Restored by Gene Therapy
| Gene therapy helped dogs
who were born with partial vision see.
The condition is known as Leber
congenital amaurosis. Infants who are affected are partially blind.
This is due to a defect of a gene called RPE65.
Scientists at the University of
Pennsylvania used retinal cells from dogs born with the genetic
disorder and infected them with a virus (rendered harmless)
carrying the normal RPE65 gene. The mixture was then injected back
into the eyes of the affected dogs.
Treated dogs responded well to light and
dark stimuli- similar to healthy dogs.
Long-term trial on the safety of this
therapy needs to be done before testing on humans begins. |
Source-
Daily University Science News 
4/19/01
An
Experimental Treatment Helps Mice with Muscular Dystrophy Disease
| Mice with similar
genetic defect as Duchenne muscular dystrophy that affects humans were
improved after treatment.
A protein, known as alpha 7 integrin, is
deficient in certain types of congenital muscular dystrophy. However,
the same protein is found more in patients with Duchenne disease.
These patients have less of other proteins important for muscular
function.
The scientists treated mice that did not
produce enough of these proteins with more of the integrin protein.
These mice did not suffer muscular problems and lived three times
longer than those of untreated mice.
Duchenne muscular dystrophy affects one
in 3,300 males. Affected individuals often die by the age of 30. |
Source- Yahoo
Biotechnology Online 
4/12/01
Gene
Involved in Back Pain
| Scientists have
discovered a gene linked to lower back pain.
The study was done in Finland on 171
people who have back pain. Their DNA sequence at a certain gene showed
up a similar mutation. The mutation does not necessarily cause the
disease, however, it predisposes those affected to back pains.
Lower back pain affects about 5% of the
population. |
Source- Yahoo
Biotechnology Online 
4/05/01
Gene
that Blocks Cancer is Located
| Scientists have
discovered a new gene that blocks cancer growth.
Cancer blocking genes are knows as tumor
suppressor genes. When working properly, they prevent cells from
growing wildly. Non-functional tumor suppressor genes lose this
ability.
The new suppressor gene that was found,
ST7, regulates the production of new blood where tumors cannot grow
out of control. ST7 is located on human chromosome 7. It is involved
in many tumors, such as brain, liver, pancreatic, skin and several
other cancers.
Data from the Human Genome Project
helped in determining the location of ST7.
Now researchers at the National
Institute of Health are studying the function of ST7. |
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