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Source- AFP Science News 

4/25/05 

Rice Fungus: Hope for the Hungry  

Scientists led by Ralph Dean of North Carolina State University, heading the International Rice Blast Genome Consortium, have decoded the genome of Magnaporthe grisea, a pathogenic plant fungus that destroys rice, the main staple of many developing countries.

M. grisea comprises windborne spores that stick to the leaves of the rice plant. As it germinates, the spore breeds a dome-shaped infection structure known as "appressorium." The fungus colonises the leaf, producing lesions from which more spores emerge and then infects other plants. 

"Rice blast is one of the most destructive diseases of rice because of its wide distribution and its destructiveness," according to the Manila-based International Rice Research Institute (IRRI).

About 0.8 percent of total yield of rice is lost in India due to the fungus. Many other losses occur in other countries, such as Japan and the Phillipines.

The fungus' DNA contains 11,109 genes which are very diverse, and produces about 739 proteins in order to penetrate and infect the rice plant.

Studying these genes can help scientists target ways to block them or by breeding plants that are resistant to them. These methods are cheaper and environmentally safer than using pesticides.

This study was published in the prestigious science journal Nature.

Source- New York Times 

3/24/05 

Nature Wonder: Plant Repairs Its Faulty Gene

Scientists at Purdue University found Arabidopsis plants that are capable of correcting a defective gene inherited from both their parents. The results are reported in the journal Nature by Dr. Robert E. Pruitt, Dr. Susan J. Lolle, and colleagues.

The researchers found that 10 percent of the plants’ offspring kept reverting to normal, and the change was traced to the DNA sequence, which is highly unusual since all corrections require a copy of the correct gene to serve as the template for the new DNA. The team scanned the DNA of the entire Arabidopsis genome for a second, cryptic copy of the targeted gene, but couldn’t find one.  

Dr. Pruitt and his colleagues speculate that a correct template must exist, not as DNA, but as RNA. He and other scientists think that it is possible that an entire RNA backup copy of the genome could exist without being detected, but under certain circumstances such as stress, the backup copy is activated.  

The discovery poses a puzzle for evolutionary theory because it corrects mutations that evolution depends on for diversity. But according to Dr. Surridge, a biology editor at Nature, this phenomenon only happens when there is something wrong.

Source- New York Times 

3/12/05 

Variant Gene Link to Risk of Vision Loss

Three separate groups of scientists have identified a variant gene that raises the risk of macular degeneration, the leading cause of severe vision loss in the elderly.  The change is in one base in the DNA and it appears to be common in the group that was studied.  

Macular degeneration is caused by damage in the macula, the central part of the retina of the eye, which is responsible for front vision. People with advanced disease, even though they still retain some peripheral vision, they are not able to drive, read, recognize faces, or watch television. 

 This variant gene might account for 20% to 50% of the risk of macular degeneration since some people in the study had the variant, but did not have the disease, while others who didn’t have the variant, had the disease. 

 The variant is a single change in a base of a gene that codes for a protein called complement factor H which is involved in the complement system, part of the body’s immune response to invading pathogens.

 One study was conducted by scientists at University of Texas Southwestern Medical Center in Dallas , Boston University , and Sequenom, a biotechnology company in San Diego . The second study was conducted at Duke and Vanderbilt, and the third study was done at Yale, National Eye Institute and the Rockefeller University .

 Dr. Johnson, co-director of the Center for the Study of Macular Degeneration at University of California , Santa Barbara , suggested that anti-inflammatory drugs, or those that specifically inhibit the complement system might one day help treat or prevent the disease, but he said that it would take years of testing to show that such drugs would prove beneficial.

 The studies are published in the journal Science.

Source- Yahoo Science News

2/15/05 

Pollution May Affect Newborns' Genes 

Scientists at Columbia University in New York City on 60 newborns and their non-smoking mothers in low-income neighborhood showed that prenatal exposure to air pollution may be linked to genetic mutations. 

The study looked at exposure of mothers-to-be during their third trimester of pregnancy to combustion-related pollutants caused primarily by vehicles. Air monitors in backpacks worn by these women were used to estimate levels of exposure..

When the babies were born, genetic changes were measured. There was about a 50 percent increase in the level of persistent genetic abnormalities in infants who had the higher levels of exposure. These type of genetic mutations have been linked in other studies to increased risk of cancer.

Source- BBC News

 Picture source: http://www.bioberedskab.dk/agens/tularaemi/tularaemi.html

1/12/05 

Genetic Code of the Super Microbe 

International scientists reported their findings of completing the genome sequence of a very infectious bacterium, known as Francisella tularensis. Their findings were published in Nature Genetics Journal.

The bacterium is a candidate bioterrorism weapon which can bring on the disease in human with only 10 microbes. It was first described as a plague-like disease of rodents in 1911 and is a potentially fatal disease in humans. The Japanese were the first to study the microbe as a germ warfare again, in a program that lasted from 1932 until 1945. The U.S. military weaponised the bacterium during the 1950s and 1960s.

The bacterium causes a disease called tularemia, or "rabbit fever" in humans and animals. Natural cases of tularemia occur across North America, Europe and Asia, and the disease can be transmitted either from tick, fly and mosquito bites or by inhaling airborne particles. People who don't die from the disease can be chronically sick for weeks or months.

Researchers have already picked out protein targets to create a vaccine. They also found a cluster of genes thought to be involved in causing illness. These genes are unique to this bacterium but it is not known how they work.  

 

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