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Source- Associated Press 

8/31/04 

Discovery of 3,000- year-old Bodies of Lapita People  

Australian scientists discovered headless bodies buried 3,000 years ago in an old cemetery that could reveal more information about the Lapita people- some of the earliest settlers of the Pacific islands and believed to be ancestors of the region's Polynesian people. The site contains the oldest human remains yet found in the region.

The skeletons would help archeologists understand better about the Lapita people, how they would have looked like, as well as their culture.

Archaeologists working at the site found the heads from adults had been removed from the bodies sometime after burial and were replaced with shell bracelets.

Source- ScienceDaily 

8/4/04 

Promising New Treatment For Heart Disease 

Scientists at Brigham and Women’s Hospital in Boston and Duke University Medical Center combined a therapeutic gene with a genetic “sensor” that recognizes and responds to the oxygen deprivation due to reduced blood flow (ischemia) in coronary artery disease and heart attack.  

The study was done on rats in which the “smart gene therapy” was administered to their hearts several weeks before inducing ischemia. This therapy protected the heart from a lot of the damage that could lead to heart failure.  

The work was led by Dzau at Brigham and Women’s Hospital. The team developed a gene construct that contains both DNA sequences that can detect oxygen deficiency and a human gene, heme-oxygenase 1, that has been shown to protect cells. The gene construct was inserted into a harmless virus, which was able to transport the therapeutic gene into the genome of the rat’s cells.  

This gene therapy method also prevented injury on rat skeletal muscle and liver in which ischemia was induced.  

Dr. Dzau predicts that the therapy might be ready to enter a phase I clinical trial in human patients in a year.  

This study is published in the journal, “Proceedings of the National Academy of Sciences” this week.

Source- BBC News 

7/1/04 

Stem Cells Therapy for Parkinson's Disease 

Researchers at Hadassah University in Israel found that when they transplanted human stem cells into the brains of rats with Parkinson's- like symptoms, the rats behavior changed. Before treatment, the rats would turn continually and were unable to make side steps while they were dragged across a surface. However, after treatment, these symptoms were significantly reduced. The stem cells in the rats developed into dopamine-producing cells.

Stem cells are early cells capable of become different type of cells with a variety of functions.

Parkinson's disease is a disorder of the central nervous system. Certain cells in the brain make a chemical substance called dopamine. Dopamine carries messages that tell the body how and when to move. Parkinson's disease occurs when these brain cells die or are damaged. There is no longer enough dopamine to carry these messages, and movement becomes more difficult. Parkinson's disease affects around 120,000 people in the United Kingdom. 

None of the treated rats developed cancerous tumors, although the rats for monitored for only 12 weeks after the transplant. Longer studies are important to rule out tumor development.

This study was the first to involve human stem cells and can set the stage for future development that may allow the use of embryonic stem cells for the treatment of Parkinson's disease. 

Source- ScienceDaily 

6/5/04 

A Simple Method for Drug Delivery 

Researchers at University of Wisconsin Medical School, the Waisman Center at UW-Madison and Mirus Bio Corporation of Madison , Wis , have discovered a solution in drug delivery that has plagued gene therapy for the past 15 years.

 The scientists used intravenous injection method to deliver DNA into the limb veins of laboratory animals of different sizes. The DNA was able to reach muscle cells and functioned effectively for an extended period of time.

 Instead of the use of viruses to carry genes inside cells, the scientists used “naked” DNA, which is devoid of protein coat that would allow the DNA to move from cell to cell and integrate into the host chromosome. As a result, naked DNA does not cause immune responses nor genetic reactions that can cause harm.

 The new delivery system also worked with proteins. One of the proteins that scientists tested was dystrophin, which is absent in Duchenne’s muscular dystrophy. The protein lasted for at least six months in the muscles of mice that lacked it. Multiple injections did not cause damage to the veins, which is important in order to maximize the percentage of therapeutic cells.

 In a similar procedure, the researchers used high-pressure injection of genes into the tail veins of rodents, which yielded extensive gene expression in the animals’ livers.  According to Dr. Wolff, the principal scientist, many laboratories around the world have successfully used this technique.

Source- ScienceDaily 

5/7/04 

Your Teeth May Help Treat Parkinson's Disease 

Scientists at the University of Michigan have shown that cells from the inside of a tooth are able to support the nerve cells that are lost in Parkinson’s disease. These cells can be transplanted into the affected areas of the brain. The study is published in the May 1 issue of the European Journal of Neuroscience with lead author Christopher Nosrat at the University of Michigan School of Dentistry.  

Dr. Nosrat was interested in testing whether the dental pulp stem cells could provide neurotrophic factors to replace dead nerve cells and support the dying cells. The procedure involved extracting a tooth and retrieving stem cells from the center of the tooth, culturing them in a Petri dish, then injecting them into brain cells.  

The scientists hope that someday, dental pulp stem cells will be an effective therapy for treating people with Parkinson’s disease.

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